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  • A nurse handles the needle used to administer patient Steve Young with his first jab

    Cancer
    ‘Real hope’ for cure as personal mRNA vaccine for melanoma trialled

    Excitement among patients and researchers as custom-built jabs enter phase 3 trial
  • Gideon Falter

    Gideon Falter
    Home Office considered campaigner for counter-extremism unit

  • An aerial view of the heavily damaged, collapsed buildings of Khan Yunis after Israeli attacks

    Live
    Egyptian delegation due in Israel seeking to kickstart Gaza ceasefire talks, say reports

  • Chris Philp on BBC One's Question Time

    Chris Philp
    Minister appears to mix up Rwanda and Congo on Question Time

    • Asia
      Wave of exceptionally hot weather scorches south and south-east of continent

    • ‘Unsustainable’
      UK predicted to see 50% spike in strokes by 2035

    • China
      Foreign minister tells US relations could slip into ‘downward spiral’

    • Ukraine
      Reparations to be paid to survivors of wartime sexual violence

    • Exclusive
      UK policy denying visas to children of care workers faces legal challenge

    • Credit cards
      Barclaycard change could mean much higher interest for some customers

News in focus

  • Gideon Falter speaking to a Metropolitan police officer during a pro-Palestine march in London

    Explained
    What is CAA, the group headed by campaigner in Met police antisemitism row?

  • Mayoral candidates over a map of the east Midlands

    ‘We end up with nothing’
    East Midlands mayoral candidates say role could transform region

    Those vying for job say it will put region on more equal footing with areas such as West Midlands and Greater Manchester
  • A mural of parachuters on the wall of a building.

    ‘We are with them’
    Support for Hamas grows among Palestinians in Lebanon

    Aspirations for statehood revived among younger generations in refugee camps where war has consumed daily life

Spotlight

  • ‘What Ryan has is a lack of insecurity about teasing himself, his stardom and his masculinity.’

    Evolution of man
    How Ryan Gosling changed stardom, cinema and society

    The actor’s feminist credentials, a wholehearted embrace of comedy and being one of the most memed actors on social media has seen Gosling’s auto-satirising alpha male become white-hot box office in 2024
  • Nia Archives with union jack tooth and red, white and blue jumper

    Mad fer it!
    The young musicians flying the flag for Britpop

  • Painting: Anthony van Dyck Wooing his Model (1827) by Gustaaf Wappers.

    Leading questions
    My partner concealed he had more than one ex-wife. Should I be nervous about our future?

    This omission demonstrates a troubling facility with concealment, writes advice columnist Eleanor Gordon-Smith
  • Elegant features in a seaside apartment in Ramsgate.

    Fantasy house hunt
    City flats for sale in Great Britain for less than £500,000

    From a modern development in the heart of Edinburgh to a Grade II-listed townhouse in Ramsgate
    • Judge illo 27th April - WEB

      You be the judge
      Should my flatmate stop setting the clocks fast – even if I am always late?

    • Taiwan's President Tsai Ing-wen speaks during a lunch meeting with Michael McCaul, Chairman of the US House Foreign Affairs Committee in April 2023

      Explainer
      What does Taiwan get from the foreign aid bill and why is the US economy among the biggest winners?

    • A young woman in a headscarf sits on a park bench

      Rights and freedom
      Married at 10, abused and forced to flee without her children: an Afghan woman on life under the Taliban

    • Joe and Kathryn’s Bargain Holidays.

      Joe and Katherine’s Bargain Holidays review
      Comedians slum it with a ‘spa day’ in a pub car park

  • Illustration: Nate Kitch

    The cost of living crisis has made the UK a poorer, more anxious nation – and worse is yet to come

    Andy Beckett
    Instead of buy-one-get-one-free offers, everyday life now involves carefully comparing prices and feeling increasingly powerless
  • The Jubilee River in Taplow, Buckinghamshire in 2023.

    Ever get the feeling that you’re being had? Presenting: the great sewage scam

    George Monbiot
  • Martin Rowson on the latest ill omen for Rishi Sunak’s government – cartoon

    Cartoon
    Martin Rowson on the latest ill omen for Rishi Sunak’s government

    Rishi Sunak’s policies invariably end in disaster
  • Yousaf's distorted reflection in a golden-framed mirror at Bute House, with a Scotland flag behind him

    Humza Yousaf forgot the rule: leaders who want to look tough look stupid

    John Crace
    Only this week the first minister said he was delighted with his coalition with the Greens. But then …
    • Gondolas by the Sospiri Bridge, near St Mark’s Square, Venice, on 2 August 2023.

      That sinking feeling: why long-suffering Venice is quite right to make tourists pay

      Simon Jenkins
    • People protest outside the supreme court

      Trump immunity case suggests new role for supreme court: kingmaker

      Martin Pengelly in Washington
    • Sewage on the River Thames in Berkshire.

      Britain’s natural landscape is in ruins – thanks to the Tories. Here’s how Labour will restore it

      Steve Reed
    • Heritage Foundation: Former Prime Minister Liz Truss on Fighting the Global Left

      Fair to say America isn’t gripped by Liz Trussmania. Here’s what she can learn from Mr Bean

      Emma Brockes

Editorials & Letters

  • First Minister Humza Yousaf delivers a speech at the University of Glasgow on Monday 8 January on the topic of the Scottish economy.

    The Guardian view
    The SNP-Greens split: an unsurprising but costly rift

  • Keir Starmer and Shadow Transport Secretary Louise Haigh visit Hitachi Rail in Aycliffe, England on 25 April  2024

    The Guardian view
    Labour and rail renationalisation: a sensible plan that passengers need

  • British Prime Minister Rishi Sunak speak to the media in Berlin, following talks with German Chancellor Olaf Scholz at the Chancellery on 24 April.

    Letters
    Rishi Sunak is punishing the sick to cover up his own failures

  • Meghan Markle, Duchess of Sussex, centre, with Serena Williams and other guests at the 2024 Royal Salute Polo Challenge in Wellington, Florida.

    Letters
    Jam is not the problem for Meghan Markle

  • Jo Brand

    Weatherwatch
    Scientists and comedians join forces to get climate crisis message across

  • UAE-WEATHER-FLOOD<br>Cars drive down a flooded motorway in Dubai on April 20, 2024. Four people died after the heaviest rainfall on record in the oil-rich UAE on April 16, including two Filipino women who suffocated inside their vehicle in Dubai's flooding. (Photo by Giuseppe CACACE / AFP) (Photo by GIUSEPPE CACACE/AFP via Getty Images)

    UAE
    Global heating and urbanisation to blame for severity of floods, study finds

  • Sculpture of a giant tap, apparently hovering in mid-air without support, pouring out a stream of discarded plastic items on to the ground

    ‘Privileged access’
    Pro-plastic lobbyists at UN pollution talks increase by a third

  • people wear shirts that say "end fossil fuels" and hold signs that say "Manchin is killing us"

    Climate crisis
    ‘Outrageous’ activists get in the faces of politicians and oil bosses – will it work?

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  • Humza Yousaf will now be forced into a series of deals with his internal critics.

    Humza Yousaf
    Greens say they will back no confidence motion

  • An older man waits at a pedestrian crossing pushing a person in a wheelchair

    Unpaid carers
    Sunak under pressure to grant amnesty to those fined for rule breaches

  • Police officers carry out searches at Kersal Dale, near Salford on Friday 5 April.

    Greater Manchester
    Two men arrested after torso found in nature reserve

  • Secondary school pupils walking in a corridor

    Education
    Just two in five pupils in England always feel safe in school, survey finds

    • Environment
      Labour says UK nature under threat and pledges to halt decline

    • Birmingham
      ‘Ludicrous’ plan to build skyscraper over Georgian building rejected

    • Laurence Fox
      Actor turned politician ordered to pay £180,000 to two people he called ‘paedophiles’

    • Wales
      Girl, 13, charged with attempted murder after school stabbings

    • Lucy Letby
      Senior judges considering whether to allow appeal

    • Reform UK
      Blackpool byelection candidate denies wrongdoing amid charity probe

  • Tractors in the streets of Krakow, Poland, as part of a protest against the EU's nature restoration law.

    Environment
    New EU nature law will fail without farmers, scientists warn

    • TikTok
      ByteDance would shut down in US rather than sell, sources say

    • Live
      Anglo American rejects BHP’s £31.1bn takeover proposal; Thoma Bravo agrees deal to buy Darktrace

    • Harvey Weinstein
      New York court overturns 2020 rape conviction

    • Emmanuel Macron
      French president criticises Rwanda-style asylum schemes days after UK passes bill

    • Technology
      Microsoft’s heavy bet on AI pays off as it beats expectations in second quarter

    • Gaza
      Leaders of 18 countries urge Hamas to release hostages

  • Haitian woman seeking healthcare

    TV tonight
    Why pregnant women are most at risk from Haiti’s gang rule

    There’s a harrowing report about the collapse of the healthcare system in the troubled country. Plus, the final episode of Beyond Paradise. Here’s what to watch this evening
  • Yuan Yang.

    Private Revolutions by Yuan Yang review
    An intimate account of how China is changing

  • David Crowell.

    David Crowell: Point/Cloud review
    Minimalism that sparkles with joy

  • ISS.

    ISS review
    Ariana DeBose is ace as third world war sparks space station survival race

  • Jeff Daniels as Charlie Croker in A Man in Full.

    A Man in Full to Shardlake
    The seven best shows to stream this week

  • Porij.

    Porij: Teething review
    Dance music without drama or daring

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    From saving money to being more environmentally friendly
    Five reasons to buy a refurbished smartphone

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    Pot of gold
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Take part

  • UKRAINE-RUSSIA-WAR-CONFLICT<br>Gunners from 43rd Separate Mechanized Brigade of the Armed Forces of Ukraine prepare to fire at Russian position with a 155 mm self-propelled howitzer 2C22 "Bohdana", in the Kharkiv region, on April 21, 2024, amid the Russian invasion in Ukraine. (Photo by Anatolii STEPANOV / AFP) (Photo by ANATOLII STEPANOV/AFP via Getty Images)

    Ukraine
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    Health
    Share your experience of accessing private medical care in the UK

  • Former Labour whip Frank Field during an interview at Portcullis House in London.

    Frank Field
    Share your memories of the former Labour minister

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    Life and style
    What’s your favourite everyday gadget?

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  • India's home minister and leader of the Bharatiya Janata Party (BJP) Amit Shah (C) greets supporters in Bengaluru, capital of Karnataka.

    India election
    Fears that Modi’s BJP will polarise voters in fight for key state

    Muslims worry Modi’s party will rely on familiar tactics of drawing on religious divisions as it battles Congress to to retain seats in Karnataka
  • Man in blue suits speaks to press behind microphones at media conference

    Harvey Weinstein
    What does ruling mean for California rape conviction?

  • Man sits at desk in court in suit and tie

    Embarrassing stories, and who pays?
    Trump hush-money trial key takeaways, day seven

  • Commuters line a platform as a metro train arrives

    ‘Confined to this little island’
    Britons criticise rejection of EU youth mobility deal

  • A former domestic worker in Beirut. About 250,000 African and Asian migrant women work in Lebanon. An average of two domestic workers a week die there.

    ‘Every day I cry’
    50 women talk about life as a domestic worker under the Gulf’s kafala system

  • Spain’s socialist prime minister, Pedro Sánchez, with his wife, Begoña Gómez, voting at the general snap election in Madrid

    Explained
    Why is Spain’s prime minister considering resigning from office?

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Pressure and Release

In Western Australia, an inspiring approach to equine therapy is helping young Indigenous Australians overcome trauma

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